Clair Obscur: Expedition 33 Guide | How to Beat the SIRÈNE Boss Fight

Preparation and Party Setup

You need to come prepared for this fight, especially if you're not familiar with the boss mechanics. One of the key challenges in this battle is the charm effect. Make sure you're keeping the cleansing tint equipped on all characters to remove status effects.

If one of your characters gets charmed, they can end up attacking and potentially eliminating your teammates. Cleansing tint prevents this from becoming a game-ender.

For Sciel, you should assign her as the party's healer. Equip her with two healing options—one that can heal the entire party and another to heal herself, because if she goes down, the rest of the party won't be able to recover. You should also boost her survivability while giving her the ability to deal strong single-target damage when needed.

Equip fire-based abilities like Spark so she can switch to her virtual stance for a more offensive role. If you've already equipped a previous character with something that doubles her damage, the bonus can stack for massive burst potential.

Don't worry about shield-related gear or abilities during this fight. Shields don't play a role here, so if you have any such items equipped, replace them with offensive or healing utilities.

Monoco should be used in a support-damage hybrid role. Equip him to apply Shell for protection and provide AP to allies. Make sure you also give him a break and mark abilities that are not AP-expensive so you can trigger them consistently to stack damage.

Include something for self-recovery and a couple of strong damage abilities. Even with some mistakes, this strategy should hold up well.

Boss Fight Strategy

Start the fight at Expeditioner difficulty, or choose a harder mode if you're looking for more of a challenge. As soon as the battle starts, be ready to evade. Time your dodges to avoid getting hit, especially when Sirène does a one-two-three combo. That pattern becomes predictable, so you can evade reliably if you pay attention.

Your goal is to stack damage quickly and control the tempo. Use healing as needed, especially if you miss a parry or mistime a dodge. If any characters fall, revive them immediately. Keeping Seal alive ensures you can always stabilize your team.

Use Spark to enter a more offensive stance when needed, especially if your current damage output feels lacking. Switching stances may give you a significant boost.

If any of your characters are charmed, use a cleansing tint right away to remove the effect and regain control. You must stay on top of this or risk losing the battle to your own teammates.

Even with several mistakes, you'll find the fight to be manageable if you prioritize high damage and anti-charm support. Keep up with your heels, watch for combo patterns, and don't hesitate to switch tactics mid-fight.

Also, check our Clair Obscur: Expedition 33 Review and other guides below:

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